VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria

@article{Demidenok2016VapCTI,
  title={VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria},
  author={Oksana I Demidenok and Mikhail S Shumkov and Anna V. Goncharenko},
  journal={Applied Biochemistry and Microbiology},
  year={2016},
  volume={52},
  pages={589-592}
}
It has been shown that inactivation of the VapC toxin from the VapВС toxin-antitoxin system prevents mycobacterial cells from transitioning to an ovoid state that meets the criteria of dormancy. The results indicate a potential target for medicines that prevent the development of latent tuberculosis infection and provide a basis to obtain bacterial cells for the testing of compounds that are active towards dormant forms of mycobacteria.