Vanishing white matter disease

  title={Vanishing white matter disease},
  author={M. S. Knaap and J. Pronk and G. Scheper},
  journal={The Lancet Neurology},
  • M. S. Knaap, J. Pronk, G. Scheper
  • Published 2006
  • Biology, Medicine
  • The Lancet Neurology
  • Vanishing white matter disease (VWM) is one of the most prevalent inherited childhood leucoencephalopathies. The classical phenotype is characterised by early childhood onset of chronic neurological deterioration, dominated by cerebellar ataxia. VWM is unusual because of its clinically evident sensitivity to febrile infections, minor head trauma, and acute fright, which may cause rapid neurological deterioration and unexplained coma. Most patients die a few years after onset. The phenotypic… CONTINUE READING
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