Vanishing Lung Syndrome (Giant Bullous Emphysema): CT Findings in 7 Patients and a Literature Review

  title={Vanishing Lung Syndrome (Giant Bullous Emphysema): CT Findings in 7 Patients and a Literature Review},
  author={Nidhi Sharma and Al Mamoon Justaniah and Jeffrey P Kanne and Jud W. Gurney and Tan Lucien H Mohammed},
  journal={Journal of Thoracic Imaging},
PURPOSE we reviewed the imaging findings in 7 patients with idiopathic giant bullous emphysema. [] Key Method On HRCT scans, the size, location, and distribution of the bullae were documented and categorized as either subpleural or central. RESULTS The HRCT scan findings in all 7 study patients included numerous bullae ranging in size from a few centimeters in diameter to giant bullae nearly filling an entire hemithorax, mimicking a pneumothorax.

Symptomatic unilateral idiopathic giant bullous emphysema : a case report

V VATS bullectomy was shown to be an effective therapeutic option, allowing re-expansion of compressed lung tissue and complete resolution of symptoms, in a solitary giant bulla occurring without major risk factors or underlying lung disease.

Vanishing Lung Syndrome: A Rare Entity -

A 20-year-old male was admitted with complaints of shortness of breath, chest pain, sweating, and tachycardia and chest X-ray and chest CT images revealed the presence of giant bullae occupying the left hemithorax and pneumothorax.

A rare case of vanishing lung syndrome with pneumothorax: importance of computed tomography

This case exemplifies role of HRCT thorax in timely diagnosis and planning appropriate treatment of VLS, and is reported in a 40-year-old male patient, who was a chronic smoker for past 20 years.

Vanishing lung syndrome vs emphysematous bulla: Two interesting cases

A rare case of a 28-year-old female patient who had no history of smoking, presented with chronic cough, expectoration and weight loss, is described, which revealed findings suggestive of giant bullous disease/vanishing lung syndrome.

Vanishing lung syndrome in one family: five cases with a 20-year follow-up.

The present study suggests that vanishing lung syndrome may be associated with autosomal dominant and recessive genetic inheritance.

The vanishing lung: an important cause of hyperlucency on chest radiograph.

This work describes two cases with this condition that presented acutely and discusses the management of bullous emphysema, a rare condition characterised by large asymmetric bullae with upper lobe predominance.

Tuberculosis-related giant bullae mimicking tension pneumothorax

A 54-year-old man presented to the emergency department with a 2-day history of worsening dyspnea on exertion and was diagnosed with TB-related giant pulmonary bullae, and bullectomy was scheduled.


A case of bullous lung disease is presented in a sixty five year old man with a clinical presentation of pneumothorax and the diagnosis was established by high resolution computed tomography of the chest.

Vanishing Lung Syndrome and Lung Volume Reduction Surgery-A Case Report

This case demonstrated that giant bullae can be successfully managed with surgical resection, and that their size can be determined by different techniques, including chest CT and lung volume measurements.

Giant bulla or pneumothorax

It is very important to make an early and quick diagnosis between giant bulla and pneumothorax before contemplating intervention, and right lung volume reduction preferably through a small incision should be the preferred treatment in this patient.



Idiopathic giant bullous emphysema (vanishing lung syndrome): imaging findings in nine patients.

Associated centrilobular emphysema, seen in cigarette smokers, is the important variable finding for determining the extent of underlying parenchymal disease, which may help in the preoperative assessment of giant bullous lung disease.

Outcomes after resection of giant emphysematous bullae.

Bullectomy for giant bullae in emphysema.

Centrilobular lesions of the lung: demonstration by high-resolution CT and pathologic correlation.

HRCT can demonstrate the location of pathologic changes within a lobule and may be helpful in the differential diagnosis of diffuse pulmonary diseases, and centrilobular emphysema and centrillobular tuberculous nodules can be diagnosed with HRCT.

Shrinking lung syndrome in systemic lupus erythematosus and Sjogren's syndrome.

The case of a 22-year-old man presenting with a 7-month history of dry mouth and dry eyes accompanied by increasing difficulty in breathing, progressing to dyspnea at rest is reported, with a diagnosis of SLE with secondary Sjogren's syndrome (SS) and SLS.

Computed tomography in the assessment of bullous lung disease.

[Computed tomographic-pathologic correlation of centriacinar emphysema].

CT extremely useful in assessing the extent of CAE, however there are limitation in the diagnosis of mild cases, and visual scoring of low-attenuation areas on CT images was found to be clinically useful in the quantitative evaluation ofCAE.

Computed tomography used to exclude pneumothorax in bullous lung disease.

In selected patients with severe bullous disease, CT may be useful, either on admission or later, when the diagnosis of pneumothorax by conventional radiographs is doubtful.

CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings.

The main value of differentiating between emphysema and other obstructive diseases of the airways is to establish a prognosis and guide the use of corticosteroid therapy by defining the degree of reversibility that can be expected in patients with limitation in air flow.

Value of computed tomography of the lung in the management of primary spontaneous pneumothorax.