Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin

@article{Szallasi1992VanilloidRL,
  title={Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin},
  author={Arpad Szallasi and Peter M. Blumberg},
  journal={Neuroscience Letters},
  year={1992},
  volume={140},
  pages={51-54}
}

analgesic effects of vanilloid receptor desensitization by capsaicin in the oral surgery model

TLDR
Data indicate that 100μg capsaicin demonstrates analgesic activity in a clinical model predictive of analgesia for vanilloid receptor ablation in humans, and may be due to incomplete receptor inactivation due to dose-limiting discomfort initially produced by sub-mucosal administration of Capsaicin and the contribution of other nociceptive fibers over time not containing TRPV1 receptors.

Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord

TLDR
Results suggest that the antagonistic effects of capsazepine were agonist‐independent, and the pharmacology of the vanilloid receptor in the rat dorsal spinal cord is not identical to that previously found in other systems.

Vanilloid-Induced Conduction Analgesia: Selective, Dose-Dependent, Long-Lasting, with a Low Level of Potential Neurotoxicity

TLDR
Data indicate possible clinical applicability of vanilloid-induced conduction analgesia, and the frequency of unmyelinated fiber degeneration was more than an order of magnitude lower than that with the therapeutic concentration of lidocaine.

Peripherally induced resiniferatoxin analgesia

[3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents

TLDR
Preincubation with heavy metal cations and other sulfhydryl-reactive agents inhibited specific [3H]RTX binding indicating that the vanilloid receptor is a thiol-protein, and that free sulfHydryl groups play an essential role in agonist binding activity.
...

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