• Corpus ID: 35118408

Vanilloid (Capsaicin) receptors and mechanisms.

@article{Szallasi1999VanilloidR,
  title={Vanilloid (Capsaicin) receptors and mechanisms.},
  author={Arpad Szallasi and Peter M. Blumberg},
  journal={Pharmacological reviews},
  year={1999},
  volume={51 2},
  pages={
          159-212
        }
}
Natural products afford a window of opportunity to study important biology. If the natural product is used or abused by human beings, finding its biological target(s) is all the more significant. Hot pepper is eaten on a daily basis by an estimated one-quarter of the world’s population and 
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References

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Capsaicin Type Pungent Agents Producing Pyrexia

Evidence for the concept that capsaicin-like pungent agents form a new class of specifically acting drugs, namely, the selective sensory neurone blocking agents, is presented and discussed in detail.

Insect antifeedant activity and hot taste for humans of selected natural and synthetic 1,4-dialdehydes.

The antifeedant activity towards larvae of Leptinotarsa decemlineata and Spodoptera littoralis and the hot taste for the human tongue have been determined for natural and synthetic 1,4-dialdehydes.…

Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules).

The pharmacological actions of capsaicin and analogues.

Capsaicin, a pungent principle present in various species of Capsicum, is a decylenic acid amide that has anti-inflammatory properties and is cytotoxic to fruit flies.

Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor

A potent cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper

Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.

Vanilloid receptors: new insights enhance potential as a therapeutic target

Potent army worm antifeedants from the east African Warburgia plants

Chemical investigation of antifeedant compounds from Warburgia plants has led to the isolation and characterization of polygodial, ugandensidial, and the unknown warburganal, which exhibit very…

Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents.

A quantitative method for measuring the efficiency of pungent agents of capsaicin-type by the pain reaction elicited on the eye of rats and a hypothetical pharmacological receptor for Capsaicin on pain sensory nerve endings is presented.
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