Vanillin inhibits PqsR-mediated virulence in Pseudomonas aeruginosa.

  title={Vanillin inhibits PqsR-mediated virulence in Pseudomonas aeruginosa.},
  author={Nicholas E. Mok and Shepherd Yuen Chan and Sylvia Yang Liu and Song Lin Chua},
  journal={Food \& function},
  volume={11 7},
Reduced efficacy of antibiotics in bacterial diseases is a global concern in clinical settings. Development of anti-virulence compounds which disarm bacterial virulence is an attractive therapeutic agent for complementary antibiotics usage. One potential target for anti-virulence compounds is quorum sensing (QS), the intercellular communication system in most pathogens, such as Pseudomonas aeruginosa. QS inhibitors (QSIs) can inhibit QS effectively, attenuate QS-mediated virulence, and improve… 
Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in Pseudomonas aeruginosa
It is suggested that paeonol attenuates bacterial virulence and infection of P. aeruginosa and that further research elucidating the anti-QS mechanism of this compound in vivo is warranted.
Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System
  • Shiwei Wang, Yuqi Feng, +4 authors Lixin Shen
  • Medicine
    International journal of molecular sciences
  • 2021
Wogonin might be used as an anti-QS candidate drug to attenuate the infection caused by P. aeruginosa PAO1 by downregulated the expression of QS-related genes and reduced the production of many virulence factors, including elastase, pyocyanin, and proteolytic enzyme.
Pyranoanthocyanins Interfering with the Quorum Sensing of Pseudomonas aeruginosa and Staphylococcus aureus
An extract and a compound of bioinspired origin were tested for their ability to inhibit biofilm formation and interfere with the expression of QS-related genes in Pseudomonas aeruginosa and Staphylococcus aureus and it was concluded that these molecules interfere with QS at distinct stages and in a strain-specific manner.
Vanillic acid combats Vibrio alginolyticus by cell membrane damage and biofilm reduction.
The findings suggested that vanillic acid may be of interest for treating V. alginolyticus-associated infections in aquaculture.
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies
The arsenal of resistance mechanisms utilized by P. aeruginosa are discussed, how these operate under high-stress environments such as the CF lung and how their interconnectedness can result in resistance to multiple antibiotic classes.
Biofilm and Quorum Sensing inhibitors: the road so far
This review provides a comprehensive focus on the development state of promising strategies against biofilm production and eradication describing chemical structures, results, administration routes, pharmaceutical compositions, and SARs as well as their shortcomings within the 2019–2020 range.
Screening of some Indonesian medicinal plant extracts for anti quorum sensing activity to prevent Aeromonas hydrophila infection in Oreochromis niloticus
Pangastuti A, Sari SLA, Budiharjo A, Fitri ST, Sayekti P, Putri SR. 2021. Screening of some Indonesian medicinal plant extracts for anti quorum sensing activity to prevent Aeromonas hydrophila
Natural compounds and extracts as novel antimicrobial agents
This review provides a comprehensive update on the development state of innovative antimicrobial agents based on natural compounds and extracts, also describing their compositions, methods of production and use, mechanism of action, and anti-microbial data when available.
Vanillin: a review on the therapeutic prospects of a popular flavouring molecule
Abstract Vanilla is the world’s most popular flavour extracted from the pods of Vanilla planifolia orchid. It is a mixture of ~ 200 compounds but its characteristic flavour and fragrance primarily
Biofilm dispersal induced by mechanical cutting leads to heightened foodborne pathogen dissemination.
This work revealed that biofilm-dispersed cells were transferred at a higher rate than planktonic cells and cutting tool was an important medium for pathogen cross-contamination, thus providing insights in maintaining their cleanliness in food processing industries.


Anti-PqsR compounds as next-generation antibacterial agents against Pseudomonas aeruginosa: A review.
Reviewing the advances in development of small molecules inhibit this protein, assist to open a new window to smart molecule design that may revolutionize treatment of P. aeruginosa infections.
Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa
The most active inhibitor, clofoctol, specifically inhibited the expression of pqs-controlled virulence traits in P. aeruginosa, such as pyocyanin production, swarming motility, biofilm formation, and expression of genes involved in siderophore production.
Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds
Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently
6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition
Test the hypothesis that 6-gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors and proves it, and offers insight into the molecular mechanism that caused QS gene repression.
The role of 2,4-dihydroxyquinoline (DHQ) in Pseudomonas aeruginosa pathogenicity
This work focused on the most abundant quinolone produced from the Pqs system, 2,4-dihydroxyquinoline (DHQ), which was shown previously to sustain pyocyanin production and antifungal activity of P. aeruginosa.
A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes
A volatile, low molecular weight molecule produced by the opportunistic human pathogen Pseudomonas aeruginosa that reduces bacterial virulence in vivo in flies and in an acute mouse infection model is identified and it is proposed that 2-AA mediates changes in a subpopulation of cells that facilitate the exploitation of dynamic host environments and promote gene expression changes that favor chronic infections.
Identification of Five Structurally Unrelated Quorum-Sensing Inhibitors of Pseudomonas aeruginosa from a Natural-Derivative Database
A structure-based virtual screening approach was used for the discovery of novel quorum-sensing inhibitors and 5 compounds were found to be able to inhibit QS-regulated gene expression in P. aeruginosa in a dose-dependent manner, demonstrating the utility of SB-VS for theiscovery of target-specific QSIs.
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.
Screening of an in-house compound library revealed two sulfur-containing compounds which possess structural resemblance with ajoene and inhibit QS in bioreporter assay, and the QS inhibition activity of the synthesized compounds is encouraging for further exploration of novel analogues in antimicrobial drug development.
Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.
Using a ligand-based approach, this work has identified the first class of PqsD inhibitors, small molecules that repress HHQ and PQS production and biofilm formation in P. aeruginosa and validates PqD as a target for the development of anti-infectives.
The hierarchy quorum sensing network in Pseudomonas aeruginosa
Quorum sensing, a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection.