Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.

  title={Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.},
  author={Sandra R. Brave and Rajesh Odedra and Neil H. James and Neil R. Smith and Gayle B. Marshall and Kerry L Acheson and Dawn J Baker and Zoe Howard and Lynsay Jackson and Kirsty E Ratcliffe and Anna Wainwright and Susan Lovick and D Mark Hickinson and Robert W. Wilkinson and Simon T. Barry and Georgina Speake and Anderson Joseph AstraZeneca R D Alderley Ryan},
  journal={International journal of oncology},
  volume={39 1},
Vandetanib is a multi-targeted receptor tyrosine kinase inhibitor that is in clinical development for the treatment of solid tumours. This preclinical study examined the inhibition of two key signalling pathways (VEGFR-2, EGFR) at drug concentrations similar to those achieved in the clinic, and their contribution to direct and indirect antitumour effects of vandetanib. For in vitro studies, receptor phosphorylation was assessed by Western blotting and ELISA, cell proliferation was assessed… CONTINUE READING
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