Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

@article{Zheng2009VandetanibZ,
  title={Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function},
  author={Li-sheng Zheng and Fang Wang and Yuan-hua Li and Xu Zhang and Li-ming Chen and Yong-ju Liang and Chun-Ling Dai and Yan-yan Yan and Li-yang Tao and Yan-jun Mi and An-Kui Yang and Kenneth Kin-Wah To and Liwu Fu},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={537 - 592}
}
BACKGROUND ABCC1 and ABCG2 are ubiquitous ATP-binding cassette transmembrane proteins that play an important role in multidrug resistance (MDR). In this study, we evaluated the possible interaction of vandetanib, an orally administered drug inhibiting multiple receptor tyrosine kinases, with ABCC1 and ABCG2 in vitro. METHODOLOGY AND PRINCIPAL FINDINGS MDR cancer cells overexpressing ABCC1 or ABCG2 and their sensitive parental cell lines were used. MTT assay showed that vandetanib had moderate… CONTINUE READING

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