Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapy.

@article{Cometta2003VancomycinVP,
  title={Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapy.},
  author={Alain Cometta and Winfried V Kern and Robrecht de Bock and Marianne Paesmans and Mike Vandenbergh and Françoise Crokaert and Dan Engelhard and Oscar Marchetti and Hamdi Akan and Athanasios Skoutelis and Volkan Korten and M Vandercam and Harold Gaya and Andrew Padmos and Jean A. Klastersky and Stephen H. Zinner and Michel Pierre Glauser and Thierry F Calandra and Claudio Viscoli},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 3},
  pages={
          382-9
        }
}
This prospective, double-blind trial assessed whether the addition of a glycopeptide would be able to reduce the time to defervescence in neutropenic patients with cancer who had persistent fever 48-60 h after the initiation of empirical piperacillin-tazobactam monotherapy. Of 763 eligible patients, 165 with persistent fever were randomized to receive piperacillin-tazobactam therapy plus either vancomycin therapy or placebo. Defervescence was observed in 82 (95%) of 86 patients in the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Incidence of single-agent gramnegative bacteremias in neutropenic cancer patients in EORTC-IATG trials of empirical therapy for febrile neutropenia [abstract L-773

  • R DeBock, A Cometta, WV Kern
  • Program and abstracts of the 41st Annual…
  • 2001
1 Excerpt

A prospective, randomized, double-blinded, placebo-controlled trial of empirical teicoplanin in febrile neutropenia with persistent fever after imipenem therapy

  • Z Erjavec, HG de Vries-Hospers, M Laseur, RM Halie, S. Daenen
  • J Antimicrob Chemother
  • 2000
1 Excerpt

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