Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with beta-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus.

@article{Craven1983VancomycinTO,
  title={Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with beta-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus.},
  author={Donald E. Craven and Nancy R. Kollisch and C R Hsieh and M G Connolly and William R. Mccabe},
  journal={The Journal of infectious diseases},
  year={1983},
  volume={147 1},
  pages={
          137-43
        }
}
The epidemiology and therapy of 29 episodes of bacteremia caused by oxacillin- and aminoglycoside-resistant Staphylococcus aureus (OARSA) were compared with 29 episodes of bacteremia due to oxacillin-sensitive S. aureus (OSSA) that occurred during a 36-month period. Patients with bacteremia due to OSSA were younger (P less than 0.05) and were admitted more frequently with acute traumatic injury (P less than 0.01). The overall survival rate one month after persistent bacteremia was 74% for… 
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Treatment of infection and colonization caused by methicillin-resistant Staphylococcus aureus.

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  • Medicine, Biology
    Infection control and hospital epidemiology
  • 1991
The mechanism of methicillin resistance confers resistance to all available beta-lactam antibiotics; consequently, beta-lactam antibiotics have no role in therapy of methicillin-resistant…

Treatment of Infection and Colonization Caused by Methicillin-Resistant Staphylococcus aureus

  • H. Chambers
  • Medicine, Biology
    Infection Control & Hospital Epidemiology
  • 1991
Abstract The mechanism of methicillin resistance confers resistance to all available B-lactam antibiotics; consequently, B-lactam antibiotics have no role in therapy of methicillin-resistant…

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Staphylococcus aureus bacteremia in patients with hematologic disorders.

Prolonged antibiotic therapy, therefore, seems warranted in patients with evident metastatic lesions, although abbreviated therapy is proposed in neutropenic cancer patients.

Implications of acquired oxacillin resistance in the management and control of Staphylococcus aureus infections.

Identifying AORSA may not be helpful in guiding antimicrobial therapy or predicting the outcome of infections with A ORSA, but this results do not suppor the contention that AorSA infections should be managed differently from OSSA infections.

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It was concluded that vancomycin is inferior to cloxacillin therapy in terminating SAB and therefore may predispose to prolonged bacteraemia and secondary seeding of infection during therapy.

Randomized study of vancomycin versus teicoplanin for the treatment of gram-positive bacterial infections in immunocompromised hosts

The immunocompromised patients with severe infection due to gram-positive organisms were randomized to receive either vancomycin or teicoplanin, and no relation was found between peak concentration in serum (at steady state) or bactericidal titers and outcome.

Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis.

A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia and explored the reasons for heterogeneity by means of subgroup analyses.

Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains.

...

26 References

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An outbreak of infections caused by strains of Staphylococcus aureus resistant to methicillin and aminoglycosides. I. Clinical studies.

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  • Medicine, Biology
    The American journal of the medical sciences
  • 1972
Methicillin‐resistance in Staphylococcus aureus is one of the major problems of gram‐positive infections in the Zurich area and is suggested that these bacteria stem from only a few preformed strains which existed prior to the introduction of antibiotics into therapy.

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It is concluded that the synergism between MET and GM, previously demonstrated for MET-susceptible S. aureus, holds true for MRSA as well and that it can be demonstrated at sub-bactericidal concentrations of GM.

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