Vancomycin pharmacokinetics in very low birth weight neonates.

  title={Vancomycin pharmacokinetics in very low birth weight neonates.},
  author={Mary B. Leonard and Gideon Koren and David K. Stevenson and Charles G. Prober},
  journal={The Pediatric infectious disease journal},
  volume={8 5},
The pharmacokinetics of vancomycin hydrochloride was studied in 12 very low birth weight infants. The gestational age (mean +/- SD) was 25.9 +/- 1.3 weeks and body weight was 769.2 +/- 151.5 g at the time of initiation of the study. Vancomycin was infused over a period of 60 minutes in a dosage of 14.2 +/- 3.2 mg/kg once daily in 10 patients, twice daily in 1 patient and every 36 hours in 1 patient for a mean of 10.5 +/- 4.9 days. Serial blood samples were obtained and the concentration time… CONTINUE READING