Vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltration.

@article{Deldot2004VancomycinPI,
  title={Vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltration.},
  author={Megan E Deldot and Jeffrey Lipman and Susan E. Tett},
  journal={British journal of clinical pharmacology},
  year={2004},
  volume={58 3},
  pages={259-68}
}
AIMS To investigate the pharmacokinetics of vancomycin in critically ill patients on continuous venovenous haemodiafiltration (CVVHDF), a continuous renal replacement therapy (CRRT) and to see if routine measures approximate vancomycin clearance. METHODS Pharmacokinetic profiles (15) of initial and steady-state doses of 750 mg twice daily intravenous vancomycin were obtained from blood and ultrafiltrate samples from 10 critically ill patients in the intensive care unit, with acute renal… CONTINUE READING
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