Vancomycin-loaded nano-hydroxyapatite pellets to treat MRSA-induced chronic osteomyelitis with bone defect in rabbits

@article{Jiang2011VancomycinloadedNP,
  title={Vancomycin-loaded nano-hydroxyapatite pellets to treat MRSA-induced chronic osteomyelitis with bone defect in rabbits},
  author={Ji-le Jiang and Yun-fei Li and Tao-lin Fang and Jian Lei Zhou and Xi-lei Li and Yi-chao Wang and Jian Dong},
  journal={Inflammation Research},
  year={2011},
  volume={61},
  pages={207-215}
}
ObjectiveTo investigate nano-hydroxyapatite (nHA) pellets as carriers for vancomycin in the treatment of chronic osteomyelitis and bone defects due to methicillin-resistant Staphylococcus aureus (MRSA) strains.MethodsChronic osteomyelitis was induced in 45 New Zealand white rabbits. After 3 weeks (chronic infection), all animals were treated with debridement. The rabbits were divided into an experimental group (the bone was filled with vancomycin-loaded nHA pellets), a control group (the bone… CONTINUE READING

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