Vancomycin induced Red Man Syndrome

  title={Vancomycin induced Red Man Syndrome},
  author={Drisyamol K.A and Mahesh Nm},
  journal={International Journal of Pharmacological Research},
Vancomycin is a glycoprotein antibiotic that has been associated with an anaphylactoid reaction termed the Red-man syndrome. It usually consists of erythema, flushing and pruritis of the face and upper torso and occasionally progresses to include dyspnoea, chest pain and hypotension. Red man syndrome (RMS) is also known as red neck syndrome. Discontinuation of the vancomycin infusion and administration of diphenhydramine can abort most of the reactions. Slow intravenous administration of… 

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Red man syndrome
Slow intravenous administration of vancomycin should minimize the risk of infusion-related adverse effects, and administration of diphenhydramine can abort most of the reactions.
Vancomycin hypersensitivity
Red man syndrome is a form of pseudoallergic drug reaction, or an adverse drug reactions with signs and symptoms that mimic immunologic drug allergies, but in which immunologic mechanisms have not been demonstrated.
Red man syndrome: an unusual complication of vancomycin beads
A case of red man syndrome is reported following usage of vancomycin impregnated cement beads which is not reported in any available orthopaedic literature.
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Possible Red-Man Syndrome Associated with Systemic Absorption of Oral Vancomycin in a Child with Normal Renal Function
This case demonstrates that significant absorption of vancomycin may occur in neutropenic patients with normal renal function, and that it may be accompanied by RMS, usually associated with rapid infusions or large parenteral doses of the drug.
Red man syndrome: incidence, etiology, and prophylaxis.
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