Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring.

@article{Zhao2013VancomycinCI,
  title={Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring.},
  author={Wei Zhao and Emmanuel Lopez and Valerie Biran and Xavier Durrmeyer and May Fakhoury and Evelyne Jacqz-Aigrain},
  journal={Archives of disease in childhood},
  year={2013},
  volume={98 6},
  pages={449-53}
}
OBJECTIVE Because pharmacokinetic data are limited, continuous infusions of vancomycin in neonates are administered using different dosing regimens. The aim of this work was to evaluate the results of vancomycin therapeutic drug monitoring (TDM) under three different dosing regimens and to optimise vancomycin therapy. METHODS Vancomycin TDM concentrations were noted and compared prospectively in three hospitals. Population pharmacokinetic analysis was performed to optimise dosing using NONMEM… CONTINUE READING
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