Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice

@article{Aggarwal2021VancomycinInducedMO,
  title={Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice},
  author={Hobby Aggarwal and Priya Pathak and Vishal Singh and Yashwant Kumar and Manoharan Shankar and Bhabatosh Das and Kumaravelu Jagavelu and Madhu Dikshit},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2021},
  volume={11}
}
The role of oxidative and nitrosative stress has been implied in both physiology and pathophysiology of metabolic disorders. Inducible nitric oxide synthase (iNOS) has emerged as a crucial regulator of host metabolism and gut microbiota activity. The present study examines the role of the gut microbiome in determining host metabolic functions in the absence of iNOS. Insulin-resistant and dyslipidemic iNOS−/− mice displayed reduced microbial diversity, with a higher relative abundance of… 

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Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin
TLDR
A crucial role of gut microbiota is suggested in the metabolic perturbations observed in iNOS-/- mice to suggest the importance of optimal redox balance.

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