Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats.

@article{Bhanot1994VanadylSP,
  title={Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats.},
  author={Sanjay Bhanot and John Hugh McNeill and M Bryer-Ash},
  journal={Hypertension},
  year={1994},
  volume={23 3},
  pages={308-12}
}
To determine whether insulin resistance and hyperinsulinemia are causally related to fructose-induced hypertension, we used vanadyl sulfate, a drug that improves insulin sensitivity in rats. Chronic oral vanadyl treatment was initiated in 6-week-old male Sprague-Dawley rats. One week after vanadyl was started, rats were fed either normal rat chow or a fructose-enriched diet. Plasma glucose and insulin levels and systolic blood pressure were measured weekly for 4 weeks. Fructose feeding induced… CONTINUE READING
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