Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils.


To determine the role of protein phosphorylation in neutrophil activation, electropermeabilized cells were treated with vanadate, a phosphatase inhibitor. Micromolar concentrations of vanadate elicited a NADPH-dependent burst of oxygen utilization in permeabilized, but not in intact cells, indicating an intracellular site of action. Stimulation of oxygen… (More)

12 Figures and Tables


  • Presentations referencing similar topics