Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species.

@article{Gao2002VanadateinducedEO,
  title={Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species.},
  author={Ning Gao and Min Ding and Jenny Z. Zheng and Zhuo Zhang and Stephen S. Leonard and Ke Jian Liu and Xianglin Shi and Bing-hua Jiang},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 35},
  pages={31963-71}
}
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of HIF-1 alpha and HIF-1 beta/aryl hydrocarbon nuclear translocator subunits. HIF-1 expression is induced by hypoxia, growth factors, and activation of oncogenes. In response to hypoxia, HIF-1 activates the expression of many genes including vascular endothelial growth factor (VEGF) and erythropoietin. HIF-1 and VEGF play an important role in angiogenesis and tumor progression. Vanadate is… CONTINUE READING

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