VanD-type vancomycin-resistant Enterococcus faecium 10/96A.

@article{Depardieu2003VanDtypeVE,
  title={VanD-type vancomycin-resistant Enterococcus faecium 10/96A.},
  author={Florence Depardieu and Peter E. Reynolds and Patrice Courvalin},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 1},
  pages={
          7-18
        }
}
VanD type Enterococcus faecium 10/96A is constitutively resistant to vancomycin and to low levels of teicoplanin by nearly exclusive synthesis of peptidoglycan precursors terminating in D-alanyl-D-lactate (L. M. Dalla Costa, P. E. Reynolds, H. A. Souza, D. C. Souza, M. F. Palepou, and N. Woodford, Antimicrob. Agents Chemother. 44:3444-3446, 2000). A G(184)S mutation adjacent to the serine involved in the binding of D-Ala1 in the D-alanine:D-alanine ligase (Ddl) led to production of an impaired… CONTINUE READING

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