Van Wyk and Grumbach Syndrome: An Unusual Presentation of Acquired Hypothyroidism


The association in young females of isosexual precocious puberty and/or polycystic ovaries, delayed bone age and hypothyroidism is known as the Van Wyk and Grumbach syndrome (VWGS). A 9-year-old girl presented with breast development, premature menarch and growth delay. An X-ray of the wrist showed a delayed bone age and laboratory data revealed high… (More)


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