Vampire Bat Salivary Plasminogen Activator (Desmoteplase): A Unique Fibrinolytic Enzyme That Does Not Promote Neurodegeneration

@article{Liberatore2003VampireBS,
  title={Vampire Bat Salivary Plasminogen Activator (Desmoteplase): A Unique Fibrinolytic Enzyme That Does Not Promote Neurodegeneration},
  author={Gabriel T. Liberatore and Andr{\'e} L. Samson and Christopher F Bladin and Wolf-Dieter Schleuning and Robert L. Medcalf},
  journal={Stroke: Journal of the American Heart Association},
  year={2003},
  volume={34},
  pages={537-543}
}
Background and Purpose— Tissue-type plasminogen activator (tPA) promotes excitotoxic and ischemic injury within the brain. These findings have implications for the use of tPA in the treatment of acute ischemic stroke. The plasminogen activator from vampire bat (Desmodus rotundus) saliva (D rotundus salivary plasminogen activator [DSPA]; desmoteplase) is an effective plasminogen activator but, in contrast to tPA, is nearly inactive in the absence of a fibrin cofactor. The purpose of this study… 

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