Valvular Aortic Stenosis in the Elderly

@article{Aronow2007ValvularAS,
  title={Valvular Aortic Stenosis in the Elderly},
  author={Wilbert S. Aronow},
  journal={Cardiology in Review},
  year={2007},
  volume={15},
  pages={217-225}
}
  • W. Aronow
  • Published 1 September 2007
  • Medicine, Biology
  • Cardiology in Review
Elderly patients with valvular aortic stenosis have an increased prevalence of coronary risk factors, of coronary artery disease, and evidence of other atherosclerotic vascular diseases. Statins may reduce the progression of aortic stenosis (AS). Angina pectoris, syncope or near syncope, and congestive heart failure are the 3 classic manifestations of severe AS. Prolonged duration and late peaking of an aortic systolic ejection murmur best differentiate severe AS from mild AS on physical… 
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Citation Type

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TLDR
AS, but not MR, was independently predictive of development of atrial fibrillation and combined valvular surgery or death, and in patients with combined AS and MR, the grade of AS, more than thegrade of MR, determined the risk of AF and combination ofValvular Surgery or death.
Targeting vasoactive peptides for managing calcific aortic valve disease
TLDR
The role of vasoactive factors in the pathogenesis of CAVD as novel pharmacological targets for the treatment of aortic valve calcification is discussed and endothelin and renin–angiotensin systems seem to be most prominent targets for therapeutic interventions in the view of valvular pathogenesis.
Geriatric Aspects of Aortic Stenosis
TLDR
The studies of Otto CM and Cosmi JE support that the histopathological property of calcific aortic valve disease represents an active process with some similarities to atherosclerosis, including lipid deposition, macrophage and T cell infiltration, basement membrane disruption and microscopic calcification.
Sustained Improvement of Left Ventricular Strain following Transcatheter Aortic Valve Replacement
TLDR
Immediate and sustained improvement in GLS was appreciated after the TAVR procedure, whether this finding continues to be noted in a more prolonged follow-up and its clinical implications need to be assessed in further studies.
Influence of prosthesis-patient mismatch on diastolic heart failure after aortic valve replacement.
Cardiac Magnetic Resonance Imaging Findings Are Useful for Differentiating Between Hypertrophic Obstructive Cardiomyopathy and Aortic Valve Stenosis in Elderly Patients
TLDR
Structural and functional parameters that are characteristic of HOCM can be assessed in cardiac MR imaging, and these parameters may be useful for differentiating between H OCM and AS in elderly patients.
Intensive lipid-lowering therapy for patients with aortic stenosis.
  • T. Pedersen
  • Medicine
    The American journal of cardiology
  • 2008
The role of echocardiography in the evaluation and management of aortic stenosis in the older adult.
Echocardiographic Evaluation of Calcific Aortic Stenosis in the Older Adult
TLDR
The value of real time three‐dimensional real time echocardiography in the assessment and management of aortic stenosis in older adults is emphasized and the critical role of various eChocardiographic modalities is emphasized.
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