Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens.


Most known human teratogens are associated with a unique or characteristic pattern of major and minor malformations and this pattern helps to establish the causal link between the teratogenic exposure and the outcome. Although traditional case-control and cohort study designs can help identify potential teratogens, there is an important role for small… (More)
DOI: 10.1111/j.1741-4520.2010.00310.x


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