Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials.

@article{Law2003ValueOL,
  title={Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials.},
  author={Malcolm R. Law and Nicholas J Wald and Joan K Morris and Rachel Elizabeth Jordan},
  journal={BMJ},
  year={2003},
  volume={326 7404},
  pages={1427}
}
OBJECTIVE To determine the average reduction in blood pressure, prevalence of adverse effects, and reduction in risk of stroke and ischaemic heart disease events produced by the five main categories of blood pressure lowering drugs according to dose, singly and in combination. DESIGN Meta-analysis of 354 randomised double blind placebo controlled trials of thiazides, beta blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists, and calcium channel… CONTINUE READING
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