Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.

@article{Sambamurti2008ValueID,
  title={Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.},
  author={Kumar Sambamurti and Miguel A. Pappolla and K. S. Jagannatha Rao},
  journal={Journal of Alzheimer's disease : JAD},
  year={2008},
  volume={14 2},
  pages={
          175-7
        }
}
Alzheimer’s disease (AD) is a progressive dementia with characteristic brain lesions known as senile plaques (SP) and neurofibrillary tangles (NFTs). Amyloid plaques contain the 38-42-residue-amyloid β protein (Aβ) and NFTs consist of the microtubule-associated protein – tau [18]. Aβ is synthesized as a larger precursor protein – AβPP – and is generated by proteolytic processing by β- and γ-secretases [15]. For a number of years, the field debated whether SP or NFTs are causes of the disease or… CONTINUE READING

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