Valsartan reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.

@article{Li2005ValsartanRI,
  title={Valsartan reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.},
  author={Quanzhong Li and Qin Deng and Jie-Qi Li and Guang-hui Yi and Shui-ping Zhao},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2005},
  volume={355 1-2},
  pages={131-6}
}
BACKGROUND Chronic low-grade inflammation response may contribute to the pathology of essential hypertension. Angiotensin II (Ang II) may be partly responsible for this process. Our early studies showed that individuals with essential hypertension had increased interleukin-1beta (IL-1beta) secretion by peripheral blood mononuclear cells (PBMCs). In this study, we investigated whether treatment with valsartan, an angiotensin receptor blocker, lowered IL-1beta secretion by PBMCs in patients with… CONTINUE READING

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