Valsartan preconditioning protects against myocardial ischemia–reperfusion injury through TLR4/NF-κB signaling pathway

Abstract

Toll-like receptor 4 (TLR4) activation has been implicated in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury. The activated TLR4 is capable of activating a variety of proinflammatory mediators, such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6). Valsartan as a kind of Angiotensin II type 1 receptor blockers is gradually used… (More)
DOI: 10.1007/s11010-009-0098-1

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Cite this paper

@article{Yang2009ValsartanPP, title={Valsartan preconditioning protects against myocardial ischemia–reperfusion injury through TLR4/NF-κB signaling pathway}, author={Jian Yang and Hong Jiang and Jun Yang and Jia-wang Ding and Li-hua Chen and Song Li and Xiao-Dong Zhang}, journal={Molecular and Cellular Biochemistry}, year={2009}, volume={330}, pages={39-46} }