Valsartan in heart failure patients previously untreated with an ACE inhibitor.

@article{Mazayev1998ValsartanIH,
  title={Valsartan in heart failure patients previously untreated with an ACE inhibitor.},
  author={V P Mazayev and Irina G. Fomina and Eduard N Kazakov and Vitaly A. Sulimov and T V Zvereva and V A Lyusov and V. A. Orlov and L I Olbinskaya and T D Bolśhakova and Joann F Sullivan and D O Spormann},
  journal={International journal of cardiology},
  year={1998},
  volume={65 3},
  pages={239-46}
}
OBJECTIVE To evaluate the effect on cardiac hemodynamic parameters of valsartan in patients with chronic stable congestive heart failure previously untreated with ACE inhibitors. METHODS After a 2 to 4 week run-in period, 116 adult outpatients were randomized to receive valsartan 40, 80 or 160 mg twice daily, the ACE inhibitor lisinopril 5/10 mg once daily, or placebo. At baseline and after 28 days of treatment, cardiac hemodynamic parameters were measured. Tolerability was assessed by… CONTINUE READING