Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

@article{Davis1994ValproicAA,
  title={Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.},
  author={Rick Davis and D. H. Peters and Donna McTavish},
  journal={Drugs},
  year={1994},
  volume={47 2},
  pages={332-72}
}
Valproic acid is a branched-chained fatty acid, structurally unrelated to any other antiepileptic drug. Since publication of the original review in the Journal in 1977, several clinical trials have documented its efficacy and safety in adults and children for the treatment of generalised seizures (absence, tonic-clonic, myoclonic), partial seizures (simple, complex, secondarily generalised) and compound/combination seizures (including those refractory to treatment with other antiepileptic drugs… CONTINUE READING

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