Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

@article{Gibbs2004ValproicAU,
  title={Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.},
  author={John P. Gibbs and Moji C Adeyeye and Ziping Yang and Danny D. Shen},
  journal={Epilepsy research},
  year={2004},
  volume={58 1},
  pages={53-66}
}
The basis for low brain permeability of valproic acid (VPA) appears to be the result of efflux transport at the blood-brain barrier (BBB); however, the identity of the putative efflux transporter has not been investigated. The objective of our studies was to determine whether the multidrug resistance-associated protein (MRP) might be involved in efflux transport of VPA. Brain microvessel endothelial cells (BMEC) were isolated from cow brains and grown to confluence. MRP messenger RNA (mRNA) in… CONTINUE READING
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