Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts

@inproceedings{Sitarz2014ValproicAT,
  title={Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts},
  author={Kamil S. Sitarz and Hannah R Elliott and Bet{\"u}l S. Karaman and Caroline Relton and Patrick F. Chinnery and Rita Horvath},
  booktitle={Molecular genetics and metabolism},
  year={2014}
}
Valproic acid (VPA) is a widely used antiepileptic drug and also prescribed to treat migraine, chronic headache and bipolar disorder. Although it is usually well tolerated, a severe hepatotoxic reaction has been repeatedly reported after VPA administration. A profound toxic reaction on administration of VPA has been observed in several patients carrying POLG mutations, and heterozygous genetic variation in POLG has been strongly associated with VPA-induced liver toxicity. Here we studied the… CONTINUE READING