Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.

@article{Umka2010ValproicAR,
  title={Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.},
  author={Jariya Umka and Sarah Mustafa and Maha ElBeltagy and Aaran Thorpe and Leith Latif and Geoffrey Bennett and Peter M. Wigmore},
  journal={Neuroscience},
  year={2010},
  volume={166 1},
  pages={15-22}
}
Valproic acid (VPA) is widely used clinically, as an anticonvulsant and mood stabilizer but is, however, also known to block cell proliferation through its ability to inhibit histone deacetylase enzymes. There have been a number of reports of cognitive impairments in patients taking VPA. In this investigation we examined the relationship between cognition and changes in cell proliferation within the hippocampus, a brain region where continued formation of new neurons is associated with learning… CONTINUE READING
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