Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells.

@article{Jeong2013ValproicAP,
  title={Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells.},
  author={Sin-Gu Jeong and Takbum Ohn and Seung Hyun Kim and Goang-Won Cho},
  journal={Neuroscience letters},
  year={2013},
  volume={554},
  pages={22-7}
}
Recent studies have shown that the inhibition of histone deacetylases (HDACs) induces the differentiation of diverse cancer and stem cells, which suggests HDAC inhibitors may be good candidates for the induction of stem cell differentiation. In this study, we investigated the effects of a HDAC inhibitor, valproic acid (VPA), for the neuronal differentiation of human bone marrow-mesenchymal stromal cells (hBM-MSCs). VPA-treated MSCs had significant increases in their expression of the neuro… CONTINUE READING

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