Valproic acid producing a Reye-like syndrome.

@article{Keene1982ValproicAP,
  title={Valproic acid producing a Reye-like syndrome.},
  author={Daniel L. Keene and Peter Humphreys and Bob Carpenter and John P. Fletcher},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1982},
  volume={9 4},
  pages={435-7}
}
.Although several cases of acute hepatic failure associated with the administration of valproic acid (VPA) have been reported, the pathogenesis of this problem remains unclear. We report the case of a 40 month old male with a chronic seizure disorder treated with VPA and phenytoin for two years, who developed sudden progressive neurological deterioration… CONTINUE READING