Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL

@article{Leiva2012ValproicAI,
  title={Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL},
  author={Magdalena Leiva and Sabrina Moretti and Hassan Soilihi and Isabella Pallavicini and Laurent P{\'e}r{\`e}s and Ciro Mercurio and Roberto dal Zuffo and Saverio Minucci and Hugues de Th{\'e}},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={1630-1637}
}
Aberrant histone acetylation was physiopathologically associated with the development of acute myeloid leukemias (AMLs). Reversal of histone deacetylation by histone deacetylase inhibitor (HDACis) activates a cell death program that allows tumor regression in mouse models of AMLs. We have used several models of PML-RARA-driven acute promyelocytic leukemias (APLs) to analyze the in vivo effects of valproic acid, a well-characterized HDACis. Valproic acid (VPA)-induced rapid tumor regression and… CONTINUE READING

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  • 2011

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