Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes.

@article{Wang2011ValproicAI,
  title={Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes.},
  author={Caiying Wang and Zuo Luan and Yinxiang Yang and Zhaoyan Wang and Ying Cui and Guixiong Gu},
  journal={Neuroscience letters},
  year={2011},
  volume={497 2},
  pages={122-7}
}
Human studies of neurodevelopment suggest that children exposed in utero to certain antiepileptic drugs (AEDs) suffer a variety of brain-behavior sequelae, such as neural tube defects, developmental delays, cognitive deficits, etc. Valproic acid (VPA), a commonly used AED, has greater risk for these side effects compared with other AEDs. However, the detailed molecular mechanisms underlying this developmental neurotoxicity of VPA is unclear despite previous research demonstrating that VPA could… CONTINUE READING
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