Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical study

@article{Routy2012ValproicAI,
  title={Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical study},
  author={J. Routy and C. Tremblay and J. Angel and B. Trottier and D. Rouleau and J. Baril and M. Harris and S. Trottier and J. Singer and N. Chomont and R. S{\'e}kaly and M. Boulassel},
  journal={HIV Medicine},
  year={2012},
  volume={13}
}
  • J. Routy, C. Tremblay, +9 authors M. Boulassel
  • Published 2012
  • Medicine
  • HIV Medicine
  • Conflicting results have been reported regarding the ability of valproic acid (VPA) to reduce the size of HIV reservoirs in patients receiving suppressive highly active antiretroviral therapy (HAART). In a randomized multicentre, cross‐over study, we assessed whether adding VPA to stable HAART could potentially reduce the size of the latent viral reservoir in CD4 T cells of chronically infected patients. 
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    References

    SHOWING 1-10 OF 23 REFERENCES
    Stability of the latent reservoir for HIV-1 in patients receiving valproic acid.
    • 176
    • PDF