Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder.

@article{Wilson2014ValproicAE,
  title={Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder.},
  author={Charles. Wilson and Leslie D. McLaughlin and Philip J. Ebenezer and Anand Nair and Joseph Francis},
  journal={Behavioural brain research},
  year={2014},
  volume={268},
  pages={72-80}
}
Reactive oxygen species (ROS) and pro-inflammatory cytokines (PIC) are upregulated in post-traumatic stress disorder (PTSD). Histone deacetylase inhibitors (HDACi) modify genetic transcription and can diminish ROS and PIC escalation. They can also modulate levels of neurotransmitters such as catecholamines and serotonin (5-HT). Thus, this study sought to analyze the effects of the HDACi valproic acid (VA) on oxidative stress, inflammation, and neurotransmitter modulation via a predator exposure… CONTINUE READING

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