Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury.

Abstract

The disruption of blood-spinal cord barrier (BSCB) after spinal cord injury (SCI) elicits an intensive local inflammation by the infiltration of blood cells such as neutrophils and macrophages, leading to cell death and permanent neurological disability. SCI activates matrix metalloprotease-9 (MMP-9), which is known to induce BSCB disruption. Here, we… (More)
DOI: 10.1111/j.1471-4159.2012.07731.x

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Cite this paper

@article{Lee2012ValproicAA, title={Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury.}, author={Jee Youn Lee and Hwang Soo Kim and Hye Young Choi and Tae H. Oh and Bong-gun Ju and Tae Young Yune}, journal={Journal of neurochemistry}, year={2012}, volume={121 5}, pages={818-29} }