Valproic acid and plasma levels of phenobarbital

@article{Bruni1980ValproicAA,
  title={Valproic acid and plasma levels of phenobarbital},
  author={J. Bruni and B. Wilder and R. Perchalski and E. Hammond and H. J. Villarreal},
  journal={Neurology},
  year={1980},
  volume={30},
  pages={94 - 94}
}
During concurrent administration of phenobarbital and valproic acid, phenobarbital plasma concentrations often increase. This often requires a reduction of phenobarbital dosage. In normal cats and patients with epilepsy, we found no evidence of decreased renal excretion of phenobarbital. Metabolic studies in four patients revealed a decrease in the conversion of phenobarbital to hydroxyphenylphenobarbital and decreased urinary ratios of hydroxyphenylphenobarbital to phenobarbital. These data… Expand
Valproic acid and plasma levels of primidone and derived phenobarbital.
  • J. Bruni
  • Chemistry, Medicine
  • The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 1981
TLDR
Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone, and no significant interaction was observed during concurrent administration of Primidone and valproIC acid. Expand
The effect of concurrent administration of valproate sodium on phenobarbital plasma concentration/dosage ratio in pediatric patients.
IN EVALUATING the possible interactions between antiepilepfic drugs, 1 the effect of valproic acid or valproate sodium on phenobarbital should be considered as a clinically significant interaction.Expand
Effect of sodium valproate and ethosuximide on phenobarbital plasma protein binding
Using defatted human plasma, sodium valproate and ethosuximide plasma protein-binding interactions with phenobarbital were assessed. Sodium valproate, but not ethosuximide, significantly displacedExpand
Hepatotoxicity of Sodium Valproate and Other Anticonvulsants in Rat Hepatocyte Cultures
TLDR
Rat hepatocyte cultures were used to test the hepatotoxicity of valproic acid and several other anticonvulsants, and it was concluded that valProic acid is a dose‐related hepatotoxin. Expand
Sodium Valproate Associated with Phenobarbital: Effects on Ammonia Metabolism in Humans
TLDR
Treatment with sodium valproate in association with phenobarbital is accompanied by a greater systemic hyperammonemia than treatment by VPA alone, and a clearer understanding of the potentiation of the secondary effects of VPA by PB is provided. Expand
Valproic acid and diazepam interaction in vivo.
TLDR
The results suggest that valproic acid displaces diazepam from plasma protein binding sites and inhibits its metabolism. Expand
Pharmacologic interactions between valproate and other drugs.
TLDR
Valproate is often administered with other antiepileptic drugs, a practice that can lead to clinically significant pharmacologic interactions, and clinical evidence of toxicity may be present at concentrations usually considered to be in the therapeutic range. Expand
Valproic acid intensifies the depressant action of phenobarbital and ethanol by a pharmacodynamic mechanism.
TLDR
Results indicate that VPA accentuates the effect of the depressant action of ethanol and PB on the central nervous system. Expand
The Effect of Valproate on the Metabolism of Phenobarbital in the Rat
TLDR
In conclusion, inhibition of PbOH formation by Valproate cannot account entirely for the increased plasma concentrations of phenobarbital that occur when valproate is added to therapy. Expand
Effects of anticonvulsants on plasma levels and entero-hepatic circulation of valproic acid and on hepatic drug metabolizing enzyme activities in rats.
TLDR
Investigation in rats found that VPA did not inhibit the hepatic drug metabolizing enzyme activities in liver in relation to their inductive effects, and Cytochrome P-450 content and glucuronyltransferase activity were enhanced following repeated coadministration with PB, DPH or CBZ. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 22 REFERENCES
Valproic acid Interaction with other anticonvulsant drugs
TLDR
The interaction of valproic acid and other antiepileptic drugs was studied in 25 patients for 5 to 9 months and careful monitoring of anticonvulsant levels is required in anticipation of the documented interactions. Expand
Rapid, simultaneous GLC determination of phenobarbital, primidone, and diphenylhydantoin.
TLDR
A rapid method is described for the simultaneous determination of phenobarbital, primidone, and diphenylhydantoin, which gives greater sensitivity and reproducibility than the short methods now in use, maintains the efficiency of much longer techniques, and takes only 45 min. Expand
Steady‐state kinetics of valproic acid in epileptic patients
TLDR
Constant levels are maintained in individual patients, but there is substantial intersubject variation. Expand
Valproate Sodium: A Controlled Clinical Trial Including Monitoring of Drug Levels
The antiepileptic effect of valproate sodium (VPA) versus that of placebo has been evaluated in a controlled clinical trial (double‐blind, crossover type). The concentration of VPA and that of otherExpand
Effect of the antiepileptic drug sodium valproate on induction of hepatic microsomal P450.
  • N. Sapeika, E. Kaplan
  • Chemistry, Medicine
  • Research communications in chemical pathology and pharmacology
  • 1975
Sodium valproate is an anticonvulsant which, unlike phenobarbitone, does not produce an increase in rat hepatic P450 when given in large nontherapeutic doses.
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
TLDR
By carrying out statistical analysis of more than 6000 assays of the serum levels of antiepileptic drugs an attempt was made to gain insight into the possible drug interactions. Expand
Analytical Data in Connection with the Clinical Use of Di-n-Propylacetate
Serum levels of dipropylacetate (DPA) (based on median scores to avoid sample spread as much as possible) have been collected from laboratory records. The only criterion for selection was a minimumExpand
A study of a drug combination: Dipropyl acetate (2-PP) and uhenobarbital
  • Pharm 28~892-896,
  • 1978
Acute intoxication during a combined treatment of sodium valproate and phenobarbitone
  • Advances in Epileptology. Amsterdam, Swets and Zeitlinger,
  • 1978
...
1
2
3
...