Valproic acid and nonalcoholic fatty liver disease: A possible association?

  title={Valproic acid and nonalcoholic fatty liver disease: A possible association?},
  author={Edoardo Farinelli and David Giampaoli and Anja Cenciarini and Ephraim Cercado and Alberto Verrotti},
  journal={World journal of hepatology},
  volume={7 9},
Valproic acid (VPA) is one of the most prescribed drugs in children with newly diagnosed epilepsy. Weight gain and obesity have been observed as side effects of VPA. These are often linked with other metabolic disturbances such as development of insulin resistance, dyslipidemia, metabolic syndrome (MetS) and non-alcoholic fatty liver disease or nonalcoholic fatty liver disease (NAFLD). NAFLD refers to a group of liver disorders with marked hepatic steatosis. It is associated with an increased… CONTINUE READING


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