Valproic acid- and lithium-sensitivity in prs mutants of Saccharomyces cerevisiae.

@article{Kleineidam2009ValproicAA,
  title={Valproic acid- and lithium-sensitivity in prs mutants of Saccharomyces cerevisiae.},
  author={Anna Kleineidam and Stefano Vavassori and Ke Wang and Lilian Mary Schweizer and Peter Gria{\vc} and Michael Schweizer},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 5},
  pages={
          1115-20
        }
}
Prs [PRPP (phosphoribosyl pyrophosphate) synthetase] catalyses the transfer of pyrophosphate from ATP to ribose 5-phosphate, thereby activating the pentose sugar for incorporation into purine and pyrimidine nucleotides. The Saccharomyces cerevisiae genome contains five genes, PRS1-PRS5, whose products display characteristic PRPP and bivalent-cation-binding sites of Prs polypeptides. Deletion of one or more of the five PRS genes has far-reaching and unexpected consequences, e.g. impaired cell… CONTINUE READING

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