Valproic acid alters mitochondrial cholesterol transport in Y1 adrenocortical cells.

@article{Brion2011ValproicAA,
  title={Valproic acid alters mitochondrial cholesterol transport in Y1 adrenocortical cells.},
  author={Laura Brion and Alejandra B Gorostizaga and Natalia V. G{\'o}mez and Ernesto J Podesta and Fabiana Cornejo Maciel and Cristina Paz},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2011},
  volume={25 1},
  pages={
          7-12
        }
}
  • L. Brion, A. Gorostizaga, C. Paz
  • Published 1 February 2011
  • Biology
  • Toxicology in vitro : an international journal published in association with BIBRA
Acute Valproate Exposure Induces Sex-Specific Changes in Steroid Hormone Metabolism in the Cerebral Cortex of Juvenile Mice
TLDR
Results indicate sex specific differences in VPA-induced steroid metabolism in the brain cortex in prepubertal mice brain.
Changes in testicular function proteins and sperm acrosome status in rats treated with valproic acid.
TLDR
Investigating the testicular proteins involved in testosterone synthesis and spermatogenesis, histopathology and sperm acrosome status in VPA-treated rats concluded that VPA treatment changes the expression oftesticular proteins responsible for sperMatogenesis and testosterone production, resulting in male infertility.
Effect of ethosuximide on cortisol metabolism in the treatment of congenital adrenal hyperplasia
TLDR
This is the first case demonstrating an interaction between ethosuximide and hydrocortisone clearance in the treatment of salt-wasting CAH, and it is provided data over 6 years demonstrating a correlation between adrenal hormone secretion, cortisol requirements and ethosUXimide dose.
Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions.
Despite the powerful induction of neurogenesis by sphingosine-1-phosphate (S1P), its study in the role of adult neurogenesis has been relatively neglected. S1P, via its differential effects at
Relationship of Mitochondria and Epilepsy Effect of Mitochondrial Disorders on Epilepsy
TLDR
The current knowledge of the effect ofmt disorders onepilepsy, of epileptic seizures onmt, and of AEDsonmt function and the implications of all these interactions for the management of epilepsy in patients with or without mt disease are reviewed.
Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).
TLDR
The incorporation of transcriptomics in the ESTn was shown to enable detection of effects, which precede morphological changes and provide a more sensitive measure of concentration-dependent effects as compared with classical morphological assessments, and mechanistic insight can be instrumental in the extrapolation of effects in theESTn to human hazard assessment.
Mitochondrial dysfunction in epilepsy.
Toxicological assessment of drugs that affect the endocrine system in puberty-related disorders
TLDR
Assessment of the effects of the drugs used in the treatment of psychiatric disorders may accentuate endocrine issues in juvenile patients and Hyperprolactinemia induction by some antipsychotics is highlighted as an example.
Interferon-Gamma and Interlukin-4 Patterns in BALB/c Mice Suffering From Cutaneous Leishmaniasis Treated With Cantharidin
TLDR
Investigation of the effect of cantharidin on Cutaneous Leishmaniasis lesions and IFN-γ and IL-4 patterns in infected BALB/c mice indicated that high doses ofCantharodin exacerbates leish maniasis lesion, but low dose of can tharid in inhibits lesion growth.
Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis
TLDR
Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%–13% in the female population and sometimes as high as 26% in female epilepsy patients.
...
...

References

SHOWING 1-10 OF 47 REFERENCES
Valproate potentiates androgen biosynthesis in human ovarian theca cells.
TLDR
The first biochemical evidence is provided to support a role for VPA in the genesis of polycystic ovary syndrome-like symptoms, and establish a direct link between VPA treatment and increased ovarian androgen biosynthesis.
An arachidonic acid-preferring acyl-CoA synthetase is a hormone-dependent and obligatory protein in the signal transduction pathway of steroidogenic hormones.
TLDR
In adrenal and Leydig cells the hormonal action prompts the synthesis of a labile protein, ACS4, which activity is involved in the regulation of AA release and is essential for steroidogenesis and StAR protein induction.
Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein*
TLDR
It is demonstrated that phosphorylated StAR interacts with voltage-dependent anion channel 1 (VDAC1) on the OMM, which then facilitates processing of the 37-kDa phospho-StAR to the 32-k da intermediate, in the absence of VDAC1.
Antisteroidogenic actions of hydrogen peroxide on rat leydig cells
TLDR
H2O2 acts directly on rat Leydig cells to diminish testosterone production by inhibiting P450scc activity and StAR protein expression and regulated steroidogenesis by diminishing protein expression of StAR.
Multiple Contributions from Long‐Chain Fatty Acid Metabolism in Y‐1 and MA‐10 Cells
TLDR
The acute effect of AA861 supports the involvement of an NDGA-insensitive lipoxygenase in the acute stimulation of mitochondrial cholesterol metabolism, and is consistent with previously reported inhibition of mitochondrial Acyl CoA ligase.
Regulation of the acute production of steroids in steroidogenic cells.
TLDR
This chapter will focus on studies designed to elucidate the mechanisms involved in the acute regulation of steroid production in response to hormone stimulation.
Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model
TLDR
VPA exposure resulted in a decrease in estradiol levels and a general downregulation of expression of genes encoding for enzymes early in steroidogenesis, and no consistent changes were seen with LEV or CBZ exposure.
...
...