Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.

@article{Tong2005ValproicAI,
  title={Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.},
  author={Vincent Tong and Xiao Wei Teng and Thomas K. H. Chang and Frank S. Abbott},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={86 2},
  pages={
          436-43
        }
}
  • Vincent Tong, Xiao Wei Teng, +1 author Frank S. Abbott
  • Published in
    Toxicological sciences : an…
    2005
  • Medicine, Biology
  • Oxidative stress has been associated with valproic acid (VPA) treatment, and mitochondrial dysfunction has been implicated in the pathogenesis of VPA-idiosyncratic hepatotoxicity. The present study investigated the effect of VPA and the role of GSH on oxidative stress, mitochondrial membrane potential, and toxicity in freshly isolated rat hepatocytes. Hepatocytes were isolated from Sprague-Dawley rats, and total levels of glutathione (GSH) reduced by pretreatment with a combination of L… CONTINUE READING

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