• Corpus ID: 22611539

Valproic acid, but not its non-teratogenic analogue 2-isopropylpentanoic acid, affects proliferation, viability and neuronal differentiation of the human teratocarcinoma cell line NTera-2.

@article{Skladchikova1998ValproicAB,
  title={Valproic acid, but not its non-teratogenic analogue 2-isopropylpentanoic acid, affects proliferation, viability and neuronal differentiation of the human teratocarcinoma cell line NTera-2.},
  author={Galina Skladchikova and Vladimir Berezin and Elisabeth Bock},
  journal={Neurotoxicology},
  year={1998},
  volume={19 3},
  pages={
          357-70
        }
}
The antiepileptic drug valproic acid (VPA) is an established human teratogen that affects neural development in human fetuses exposed to the drug during early pregnancy. The development of simple cell culture models that reflect normal neuronal development will be useful for the screening of neural developmental toxicity of new drugs and for the identification of the specific molecular targets for the teratogenic action. The present study tests a human NT2 cell line for its suitability to serve… 

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    Toxicology in vitro : an international journal published in association with BIBRA
  • 2014

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