Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition.

@article{Jeong2003ValproicAA,
  title={Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition.},
  author={Mi Ra Jeong and Ryota Hashimoto and Vladimir V. Senatorov and Koichiro Fujimaki and Ming Ren and Min Soo Lee and D. -M. Chuang},
  journal={FEBS letters},
  year={2003},
  volume={542 1-3},
  pages={74-8}
}
We studied the neuroprotective effects of valproic acid (VPA), a primary mood stabilizer and anticonvulsant, in cultured rat cerebral cortical neurons (CCNs). CCNs underwent spontaneous cell death when their age increased in culture. As shown by mitochondrial activity and calcein-AM assays, treatment of CCNs with VPA starting from day 9 in vitro markedly increased viability and prolonged the life span of the cultures. The neuroprotective action of VPA was time-dependent and occurred at… CONTINUE READING