Valproic Acid and Fatalities in Children: A Review of Individual Case Safety Reports in VigiBase

Abstract

INTRODUCTION Valproic acid is an effective first line drug for the treatment of epilepsy. Hepatotoxicity is a rare and potentially fatal adverse reaction for this medicine. OBJECTIVE Firstly to characterise valproic acid reports on children with fatal outcome and secondly to determine reporting over time of hepatotoxicity with fatal outcome. METHODS… (More)
DOI: 10.1371/journal.pone.0108970

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