Valproic Acid Toxicity: Overview and Management

  title={Valproic Acid Toxicity: Overview and Management},
  author={M. Sztajnkrycer},
  journal={Journal of Toxicology: Clinical Toxicology},
  pages={789 - 801}
  • M. Sztajnkrycer
  • Published 2002
  • Medicine
  • Journal of Toxicology: Clinical Toxicology
  • Acute valproic acid intoxication is an increasing problem, accounting for more than 5000 calls to the American Association of Poison Control Centers in 2000. The purpose of this paper is to review the pharmacology and toxicology of valproic acid toxicity. Unlike earlier antiepileptic agents, valproic acid appears to function neither through sodium channel inhibition nor through direct γ-aminobutyric acid agonism, but through an indirect increase in regional brain γ-aminobutyric acid levels… CONTINUE READING
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