Valproic Acid Toxicity: Overview and Management

@article{Sztajnkrycer2002ValproicAT,
  title={Valproic Acid Toxicity: Overview and Management},
  author={M. Sztajnkrycer},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2002},
  volume={40},
  pages={789 - 801}
}
  • M. Sztajnkrycer
  • Published 2002
  • Medicine
  • Journal of Toxicology: Clinical Toxicology
  • Acute valproic acid intoxication is an increasing problem, accounting for more than 5000 calls to the American Association of Poison Control Centers in 2000. The purpose of this paper is to review the pharmacology and toxicology of valproic acid toxicity. Unlike earlier antiepileptic agents, valproic acid appears to function neither through sodium channel inhibition nor through direct γ-aminobutyric acid agonism, but through an indirect increase in regional brain γ-aminobutyric acid levels… CONTINUE READING
    177 Citations
    Carnitine as an antidote for acute valproate toxicity in children
    • S. Russell
    • Medicine
    • Current opinion in pediatrics
    • 2007
    • 46
    Carnitine in the treatment of valproic acid-induced toxicity
    • 188
    Extracorporeal elimination in acute valproic acid poisoning
    • 33
    • Highly Influenced
    Delayed Toxicity of a Patient with Valproic Acid Overdose
    • PDF
    Acute Valproate Poisoning: Pharmacokinetics, Alteration in Fatty Acid Metabolism, and Changes During Therapy
    • 69
    Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination
    • 12
    Disposition of valproic acid in self-poisoned adults.
    • 6

    References

    SHOWING 1-10 OF 126 REFERENCES
    Valproic acid overdose and L-carnitine therapy.
    • 62
    • Highly Influential
    • PDF
    The Role of Carnitine Supplementation during Valproic Acid Therapy
    • 124
    • Highly Influential
    Valproic acid toxicokinetics: serial hemodialysis and hemoperfusion.
    • 55
    • Highly Influential
    Multicenter Case Series of Valproic Acid Ingestion: Serum Concentrations and Toxicity
    • 124
    • Highly Influential
    Valproate-Induced Coma: Case Report and Literature Review
    • 81
    Valproic acid and the liver.
    • 79
    • Highly Influential
    • PDF
    Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.
    • 32
    Acute valproate intoxication: biochemical investigations and hemodialysis treatment.
    • 55
    • Highly Influential