Valproic Acid Alters Angiogenic and Trophic Gene Expression in Human Prostate Cancer Models.

Abstract

BACKGROUND/AIM Only a minority of men succumb to prostate cancer (PCa). Therapy to prevent progression would change treatment paradigms. We investigated the effect of valproic acid (VPA) on PCa cell proliferation and the effects on both angiogenesis and PCa-specific signaling. MATERIALS AND METHODS LNCaP cells were treated with VPA for 72 h and… (More)

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